Ontology highlight
ABSTRACT:
SUBMITTER: Cho EC
PROVIDER: S-EPMC3227810 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Cho Eun Chul EC Zhang Qiang Q Xia Younan Y
Nature nanotechnology 20110424 6
In vitro experiments typically measure the uptake of nanoparticles by exposing cells at the bottom of a culture plate to a suspension of nanoparticles, and it is generally assumed that this suspension is well-dispersed. However, nanoparticles can sediment, which means that the concentration of nanoparticles on the cell surface may be higher than the initial bulk concentration, and this could lead to increased uptake by cells. Here, we use upright and inverted cell culture configurations to show ...[more]