DFMO: targeted risk reduction therapy for colorectal neoplasia.
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ABSTRACT:
SUBMITTER: Laukaitis CM
PROVIDER: S-EPMC3227870 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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DFMO: targeted risk reduction therapy for colorectal neoplasia.
Laukaitis Christina M CM Gerner Eugene W EW
Best practice & research. Clinical gastroenterology 20110801 4-5
Strategies to decrease intracellular polyamine levels have been studied for their efficacy in reducing colorectal cancer (CRC) risk. A successful strategy combined agents that decreased polyamine synthesis by inhibiting ornithine decarboxylase with difluoromethylornithine (DFMO), and increased cellular export of polyamines by activating the spermidine/spermine acetyl transferase with non-steroidal anti-inflammatory drugs (NSAIDs). A Phase III trial treating resected adenoma patients with DFMO pl ...[more]
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