Ontology highlight
ABSTRACT:
SUBMITTER: Sholler GLS
PROVIDER: S-EPMC6160434 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sholler Giselle L Saulnier GLS Ferguson William W Bergendahl Genevieve G Bond Jeffrey P JP Neville Kathleen K Eslin Don D Brown Valerie V Roberts William W Wada Randal K RK Oesterheld Javier J Mitchell Deanna D Foley Jessica J Parikh Nehal S NS Eshun Francis F Zage Peter P Rawwas Jawhar J Sencer Susan S Pankiewicz Debra D Quinn Monique M Rich Maria M Junewick Joseph J Kraveka Jacqueline M JM
Scientific reports 20180927 1
High risk neuroblastoma (HRNB) accounts for 15% of all pediatric cancer deaths. Despite aggressive therapy approximately half of patients will relapse, typically with only transient responses to second-line therapy. This study evaluated the ornithine decarboxylase inhibitor difluoromethylornithine (DFMO) as maintenance therapy to prevent relapse following completion of standard therapy (Stratum 1) or after salvage therapy for relapsed/refractory disease (Stratum 2). This Phase II single agent, s ...[more]