Dataset Information

?-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking.

ABSTRACT: Extensive work in humans using magneto- and electroencephalography strongly suggests that decreased oscillatory ?-activity (8-14 Hz) facilitates processing in a given region, whereas increased ?-activity serves to actively suppress irrelevant or interfering processing. However, little work has been done to understand how ?-activity is linked to neuronal firing. Here, we simultaneously recorded local field potentials and spikes from somatosensory, premotor, and motor regions while a trained monkey performed a vibrotactile discrimination task. In the local field potentials we observed strong activity in the ?-band, which decreased in the sensorimotor regions during the discrimination task. This ?-power decrease predicted better discrimination performance. Furthermore, the ?-oscillations demonstrated a rhythmic relation with the spiking, such that firing was highest at the trough of the ?-cycle. Firing rates increased with a decrease in ?-power. These findings suggest that ?-oscillations exercise a strong inhibitory influence on both spike timing and firing rate. Thus, the pulsed inhibition by ?-oscillations plays an important functional role in the extended sensorimotor system.

SUBMITTER: Haegens S

PROVIDER: S-EPMC3228466 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking.

Haegens Saskia S Nácher Verónica V Luna Rogelio R Romo Ranulfo R Jensen Ole O

Proceedings of the National Academy of Sciences of the United States of America 20111114 48

Extensive work in humans using magneto- and electroencephalography strongly suggests that decreased oscillatory α-activity (8-14 Hz) facilitates processing in a given region, whereas increased α-activity serves to actively suppress irrelevant or interfering processing. However, little work has been done to understand how α-activity is linked to neuronal firing. Here, we simultaneously recorded local field potentials and spikes from somatosensory, premotor, and motor regions while a trained monke ...[more]

PMID: 22084106

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Project description:Prefrontal cortex (PFC) are broadly linked to various aspects of behavior. During sensory discrimination, PFC neurons can encode a range of task related information, including the identity of sensory stimuli and related behavioral outcome. However, it remains largely unclear how different neuron subtypes and local field potential (LFP) oscillation features in the mouse PFC are modulated during sensory discrimination. To understand how excitatory and inhibitory PFC neurons are selectively engaged during sensory discrimination and how their activity relates to LFP oscillations, we used tetrode recordings to probe well-isolated individual neurons, and LFP oscillations, in mice performing a three-choice auditory discrimination task. We found that a majority of PFC neurons, 78% of the 711 recorded individual neurons, exhibited sensory discrimination related responses that are context and task dependent. Using spike waveforms, we classified these responsive neurons into putative excitatory neurons with broad waveforms or putative inhibitory neurons with narrow waveforms, and found that both neuron subtypes were transiently modulated, with individual neurons' responses peaking throughout the entire duration of the trial. While the number of responsive excitatory neurons remain largely constant throughout the trial, an increasing fraction of inhibitory neurons were gradually recruited as the trial progressed. Further examination of the coherence between individual neurons and LFPs revealed that inhibitory neurons exhibit higher spike-field coherence with LFP oscillations than excitatory neurons during all aspects of the trial and across multiple frequency bands. Together, our results demonstrate that PFC excitatory neurons are continuously engaged during sensory discrimination, whereas PFC inhibitory neurons are increasingly recruited as the trial progresses and preferentially coordinated with LFP oscillations. These results demonstrate increasing involvement of inhibitory neurons in shaping the overall PFC dynamics toward the completion of the sensory discrimination task.

Dataset Information

?-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking.

Publications

α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking.

Similar Datasets

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