Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez-Sanchez MS
PROVIDER: S-EPMC3228816 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Domínguez-Sánchez María S MS Barroso Sonia S Gómez-González Belén B Luna Rosa R Aguilera Andrés A
PLoS genetics 20111201 12
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a differential implication of mRNP biogenesis factors in genome integrity in yeast and humans. We show that human THO depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and γH2AX and 53BP1 foci accumulation. This is accompanied by replication alteration as determined ...[more]