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The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

ABSTRACT: Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.

SUBMITTER: Blanco S

PROVIDER: S-EPMC3228827 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

Blanco Sandra S Kurowski Agata A Nichols Jennifer J Watt Fiona M FM Benitah Salvador Aznar SA Frye Michaela M

PLoS genetics 20111201 12

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enha ...[more]

PMID: 22144916

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