Ontology highlight
ABSTRACT:
SUBMITTER: Cai X
PROVIDER: S-EPMC4991368 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cai Xiaoyu X Hu Yuanyuan Y Tang Hao H Hu Han H Pang Lijun L Xing Junyue J Liu Zhenyun Z Luo Yuhong Y Jiang Bin B Liu Te T Gorospe Myriam M Chen Chuan C Wang Wengong W
Oncotarget 20160401 15
The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC. Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK ...[more]