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ABSTRACT:
SUBMITTER: Agnihotri G
PROVIDER: S-EPMC3228886 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Agnihotri Geetanjali G Crall Breanna M BM Lewis Tyler C TC Day Timothy P TP Balakrishna Rajalakshmi R Warshakoon Hemamali J HJ Malladi Subbalakshmi S SS David Sunil A SA
Journal of medicinal chemistry 20111104 23
Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-R-cysteinyl-S-serine (PAM(2)CS) compounds are potential vaccine adjuvants. In continuation of previously reported structure-activity relationships on this chemotype, we have determined that at least one acyl group of optimal length (C(16)) and an appropriately oriented ester carbonyl group is essential for TLR2-agonistic activity. The spacing between one of the palmitoyl ester carbonyl and the thioethe ...[more]