Ontology highlight
ABSTRACT:
SUBMITTER: Kokatla HP
PROVIDER: S-EPMC4105021 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kokatla Hari Prasad HP Sil Diptesh D Tanji Hiromi H Ohto Umeharu U Malladi Subbalakshmi S SS Fox Lauren M LM Shimizu Toshiyoki T David Sunil A SA
ChemMedChem 20140128 4
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds might be promising candidate vaccine adjuvants. Recently, a C2-butyl furo[2,3-c]quinoline was reported with purely TLR8 agonistic activity. This compound was successfully co-crystallized with the human TLR8 ectodomain, and the co-crystal structure revealed ligand-induced reorganization of the binding pocket of TLR8. The los ...[more]