Ontology highlight
ABSTRACT:
SUBMITTER: Witze ES
PROVIDER: S-EPMC3229220 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Witze Eric S ES Litman Elizabeth S ES Argast Gretchen M GM Moon Randall T RT Ahn Natalie G NG
Science (New York, N.Y.) 20080401 5874
Mechanisms by which Wnt pathways integrate the organization of receptors, organelles, and cytoskeletal proteins to confer cell polarity and directional cell movement are incompletely understood. We show that acute responses to Wnt5a involve recruitment of actin, myosin IIB, Frizzled 3, and melanoma cell adhesion molecule into an intracellular structure in a melanoma cell line. In the presence of a chemokine gradient, this Wnt-mediated receptor-actin-myosin polarity (W-RAMP) structure accumulates ...[more]