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New polyether triterpenoids from Laurencia viridis and their biological evaluation.

ABSTRACT: The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.

SUBMITTER: Pacheco FC

PROVIDER: S-EPMC3229232 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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New polyether triterpenoids from Laurencia viridis and their biological evaluation.

Pacheco Francisco Cen FC Villa-Pulgarin Janny A JA Mollinedo Faustino F Martín Manuel Norte MN Fernández José Javier JJ Daranas Antonio Hernández AH

Marine drugs 20111107 11

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new ...[more]

PMID: 22163183

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