Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC3229304 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Xu Wei W Yang Hui H Liu Ying Y Yang Ying Y Wang Ping P Kim Se-Hee SH Ito Shinsuke S Yang Chen C Wang Pu P Xiao Meng-Tao MT Liu Li-xia LX Jiang Wen-qing WQ Liu Jing J Zhang Jin-ye JY Wang Bin B Frye Stephen S Zhang Yi Y Xu Yan-hui YH Lei Qun-ying QY Guan Kun-Liang KL Zhao Shi-min SM Xiong Yue Y
Cancer cell 20110101 1
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarate (2-HG), respectively. Here we demonstrate that 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. 2-HG occupies the same space as α-KG does in the active site of histone demethylases. Ectop ...[more]