Ontology highlight
ABSTRACT:
SUBMITTER: Carbonneau M
PROVIDER: S-EPMC5027283 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160914
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of isocitrate into α-ketoglutarate (αKG). In gliomas and acute myeloid leukaemias, IDH1/2 mutations confer gain-of-function leading to production of the oncometabolite R-2-hydroxyglutarate (2HG) from αKG. H ...[more]