Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa T
PROVIDER: S-EPMC3230935 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Nakagawa Tadashi T Xiong Yue Y
Molecular cell 20110801 3
CUL4B, encoding a scaffold protein for the assembly of Cullin4B-Ring ubiquitin ligase (CRL4B) complexes, is frequently mutated in X-linked mental retardation (XLMR) patients. Here, we show that CUL4B, but not its paralog, CUL4A, targets WDR5, a core subunit of histone H3 lysine 4 (H3K4) methyltransferase complexes, for ubiquitylation and degradation in the nucleus. Knocking down CUL4B increases WDR5 and trimethylated H3K4 (H3K4me3) on the neuronal gene promoters and induces their expression. Fur ...[more]