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Biofunctionalized zinc oxide field effect transistors for selective sensing of riboflavin with current modulation.

ABSTRACT: Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag (ferrocene) to the 3' terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels.

SUBMITTER: Hagen JA

PROVIDER: S-EPMC3231651 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Biofunctionalized zinc oxide field effect transistors for selective sensing of riboflavin with current modulation.

Hagen Joshua A JA Kim Sang N SN Bayraktaroglu Burhan B Leedy Kevin K Chávez Jorge L JL Kelley-Loughnane Nancy N Naik Rajesh R RR Stone Morley O MO

Sensors (Basel, Switzerland) 20110627 7

Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by cova ...[more]

PMID: 22163977

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