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ABSTRACT:
SUBMITTER: Saino H
PROVIDER: S-EPMC3232166 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Saino Hiromichi H Ago Hideo H Ukita Yoko Y Miyano Masashi M
Acta crystallographica. Section F, Structural biology and crystallization communications 20111129 Pt 12
Dodecyl-β-D-selenomaltoside (SeDDM) is a seleno-detergent with a β-glycosidic seleno-ether in place of the ether moiety in dodecyl-β-D-maltoside. Seleno-detergents are candidates for heavy-atom agents in experimental phasing of membrane proteins in protein crystallography. Crystals of a nuclear membrane-embedded enzyme, leukotriene C(4) synthase (LTC(4)S), in complex with SeDDM were prepared and a multiwavelength anomalous diffraction (MAD) experiment was performed. The SeDDM in the LTC(4)S crys ...[more]