Ontology highlight
ABSTRACT:
SUBMITTER: Segurel L
PROVIDER: S-EPMC3232208 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
PLoS biology 20111206 12
During mammalian meiosis, double-strand breaks are deliberately made throughout the genome and then repaired, leading to the exchange of genetic material between copies of chromosomes. How the locations of breaks are specified was largely unknown until a fortuitous confluence of statistical genetics and molecular biology uncovered the role of PRDM9, a DNA binding protein. Many properties of this protein remain mysterious, however, including how it binds to DNA, how it contributes to male inferti ...[more]