Ontology highlight
ABSTRACT:
SUBMITTER: Upadhyay AK
PROVIDER: S-EPMC3232282 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20110825 6
Both components of chromatin (DNA and histones) are subjected to dynamic postsynthetic covalent modifications. Dynamic histone lysine methylation involves the activities of modifying enzymes (writers), enzymes removing modifications (erasers), and readers of the epigenetic code. Known histone lysine demethylases include flavin-dependent monoamine oxidase lysine-specific demethylase 1 and α-ketoglutarate-Fe(II)-dependent dioxygenases containing Jumonji domains. Importantly, the Jumonji domain oft ...[more]