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Chemical probes for methyl lysine reader domains.

ABSTRACT: The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysine reader domains with a focus on recent progress targeting chromodomains.

SUBMITTER: James LI

PROVIDER: S-EPMC5018434 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Chemical probes for methyl lysine reader domains.

James Lindsey I LI Frye Stephen V SV

Current opinion in chemical biology 20160625

The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysi ...[more]

PMID: 27348158

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