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How focal adhesion kinase achieves regulation by linking ligand binding, localization and action.

ABSTRACT: Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.

SUBMITTER: Arold ST

PROVIDER: S-EPMC3232291 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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How focal adhesion kinase achieves regulation by linking ligand binding, localization and action.

Arold Stefan T ST

Current opinion in structural biology 20111024 6

Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging unders ...[more]

PMID: 22030387

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Focal Adhesion Kinase Dependent Expression

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