Regulation of cellular metabolism by protein lysine acetylation.
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ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC3232675 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Regulation of cellular metabolism by protein lysine acetylation.
Zhao Shimin S Xu Wei W Jiang Wenqing W Yu Wei W Lin Yan Y Zhang Tengfei T Yao Jun J Zhou Li L Zeng Yaxue Y Li Hong H Li Yixue Y Shi Jiong J An Wenlin W Hancock Susan M SM He Fuchu F Qin Lunxiu L Chin Jason J Yang Pengyuan P Chen Xian X Lei Qunying Q Xiong Yue Y Guan Kun-Liang KL
Science (New York, N.Y.) 20100201 5968
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver ti ...[more]
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