Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
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ABSTRACT:
SUBMITTER: Ali I
PROVIDER: S-EPMC6609103 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali Ibraheem I Conrad Ryan J RJ Verdin Eric E Ott Melanie M
Chemical reviews 20180206 3
Post-translational acetylation of lysine residues has emerged as a key regulatory mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique modification of histones, acetylation marks are now found on thousands of nonhistone proteins located in virtually every cellular compartment. Here we summarize key findings in the field of protein acetylation over the past 20 years with a focus on recent discoveries in nuclear, cytoplasmic, and mitochondrial compartments. Collectively ...[more]
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