Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
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ABSTRACT:
SUBMITTER: Eisele YS
PROVIDER: S-EPMC3233904 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
Eisele Yvonne S YS Obermüller Ulrike U Heilbronner Götz G Baumann Frank F Kaeser Stephan A SA Wolburg Hartwig H Walker Lary C LC Staufenbiel Matthias M Heikenwalder Mathias M Jucker Mathias M
Science (New York, N.Y.) 20101021 6006
The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times. ...[more]
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