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Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.

ABSTRACT: The development of a highly effective AIDS vaccine will likely depend on success in designing immunogens that elicit broadly neutralizing antibodies to naturally circulating strains of HIV-1. Although the antibodies induced after natural infection with HIV-1 are often directed to strain-specific or nonneutralizing determinants, it is now evident that 10%-25% of HIV-infected individuals generate neutralizing antibody responses of considerable breadth. In the past, only four broadly neutralizing monoclonal antibodies had been defined, but more than a dozen monoclonal antibodies of substantial breadth have more recently been isolated. An understanding of their recognition sites, the structural basis of their interaction with the HIV Env, and their development pathways provides new opportunities to design vaccine candidates that will elicit broadly protective antibodies against this virus.

SUBMITTER: Kwong PD

PROVIDER: S-EPMC3234457 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.

Kwong Peter D PD Mascola John R JR Nabel Gary J GJ

Cold Spring Harbor perspectives in medicine 20110901 1

The development of a highly effective AIDS vaccine will likely depend on success in designing immunogens that elicit broadly neutralizing antibodies to naturally circulating strains of HIV-1. Although the antibodies induced after natural infection with HIV-1 are often directed to strain-specific or nonneutralizing determinants, it is now evident that 10%-25% of HIV-infected individuals generate neutralizing antibody responses of considerable breadth. In the past, only four broadly neutralizing m ...[more]

PMID: 22229123

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