Ontology highlight
ABSTRACT:
SUBMITTER: Kwong PD
PROVIDER: S-EPMC3234457 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Kwong Peter D PD Mascola John R JR Nabel Gary J GJ
Cold Spring Harbor perspectives in medicine 20110901 1
The development of a highly effective AIDS vaccine will likely depend on success in designing immunogens that elicit broadly neutralizing antibodies to naturally circulating strains of HIV-1. Although the antibodies induced after natural infection with HIV-1 are often directed to strain-specific or nonneutralizing determinants, it is now evident that 10%-25% of HIV-infected individuals generate neutralizing antibody responses of considerable breadth. In the past, only four broadly neutralizing m ...[more]