Ontology highlight
ABSTRACT:
SUBMITTER: Lee KM
PROVIDER: S-EPMC3234674 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lee Kit Ming KM McKimmie Clive S CS Gilchrist Derek S DS Pallas Kenneth J KJ Nibbs Robert J RJ Garside Paul P McDonald Victoria V Jenkins Christopher C Ransohoff Richard R Liu Liping L Milling Simon S Cerovic Vuk V Graham Gerard J GJ
Blood 20111006 23
Lymphatic endothelial cells are important for efficient flow of antigen-bearing fluid and antigen-presenting cells (APCs) from peripheral sites to lymph nodes (LNs). APC movement to LNs is dependent on the constitutive chemokine receptor CCR7, although how conflicting inflammatory and constitutive chemokine cues are integrated at lymphatic surfaces during this process is not understood. Here we reveal a previously unrecognized aspect of the regulation of this process. The D6 chemokine-scavenging ...[more]