Ontology highlight
ABSTRACT:
SUBMITTER: Sweet DT
PROVIDER: S-EPMC4563745 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Sweet Daniel T DT Jiménez Juan M JM Chang Jeremy J Hess Paul R PR Mericko-Ishizuka Patricia P Fu Jianxin J Xia Lijun L Davies Peter F PF Kahn Mark L ML
The Journal of clinical investigation 20150727 8
Fluid shear forces have established roles in blood vascular development and function, but whether such forces similarly influence the low-flow lymphatic system is unknown. It has been difficult to test the contribution of fluid forces in vivo because mechanical or genetic perturbations that alter flow often have direct effects on vessel growth. Here, we investigated the functional role of flow in lymphatic vessel development using mice deficient for the platelet-specific receptor C-type lectin-l ...[more]