Ontology highlight
ABSTRACT:
SUBMITTER: Trost BM
PROVIDER: S-EPMC3235049 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Trost Barry M BM Malhotra Sushant S Olson David E DE Maruniak Autumn A Du Bois J J
Journal of the American Chemical Society 20090401 12
The use of a bifunctional nitrogen nucleophile and an allyl carbonate starting material in successive enantioselective palladium- and diastereoselective rhodium-catalyzed reactions enables the rapid assembly of unique amino aziridine products. Further elaboration of these materials affords complex, stereodefined polyamine architectures, thus demonstrating the power of these combined methods for simplifying asymmetric C-N bond construction. ...[more]