Asymmetric synthesis of chiral cycloalkenone derivatives via palladium catalysis.
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ABSTRACT: The palladium-catalyzed oxidative desymmetrization of meso dibenzoates yields γ-benzoyloxy cycloalkenones in good yields and with excellent levels of enantioselectivity. These compounds serve as precursors to a broad range of substituted cycloalkenones, including well-established synthetic building blocks and elaborated cycloalkanone derivatives. The ability to prepare both enantiomers of the oxidative desymmetrization products enables a unified strategy toward stereochemically diverse epoxyquinoid natural products.
SUBMITTER: Trost BM
PROVIDER: S-EPMC3992253 | biostudies-literature |
REPOSITORIES: biostudies-literature
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