Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling.
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ABSTRACT: A unified, convenient, and efficient strategy for the preparation of rhodamines and N,N'-diacylated rhodamines has been developed. Fluorescein ditriflates were found to undergo palladium-catalyzed C-N cross-coupling with amines, amides, carbamates, and other nitrogen nucleophiles to provide direct access to known and novel rhodamine derivatives, including fluorescent dyes, quenchers, and latent fluorophores.
SUBMITTER: Grimm JB
PROVIDER: S-EPMC3235915 | biostudies-literature |
REPOSITORIES: biostudies-literature
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