Ontology highlight
ABSTRACT:
SUBMITTER: Bosmann M
PROVIDER: S-EPMC3236631 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Bosmann Markus M Patel Vinay R VR Russkamp Norman F NF Pache Florence F Zetoune Firas S FS Sarma J Vidya JV Ward Peter A PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110822 12
The interleukin-17 (IL-17) family of cytokines plays important roles in innate immune defenses against bacterial and fungal pathogens. While much is known about IL-17A, much less information is available about the IL-17F isoform. Here, we investigated gene expression and release of IL-17F and its regulation by the complement system. IL-17F was produced in mouse peritoneal elicited macrophages after TLR4 activation by LPS, peaking after 12 h. This effect was completely dependent on the presence o ...[more]