Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway.
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ABSTRACT:
SUBMITTER: Mijares LA
PROVIDER: S-EPMC3110630 | biostudies-other | 2011 Jun
REPOSITORIES: biostudies-other
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Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway.
Mijares Lilia A LA Wangdi Tamding T Sokol Caroline C Homer Robert R Medzhitov Ruslan R Kazmierczak Barbara I BI
Journal of immunology (Baltimore, Md. : 1950) 20110513 12
The opportunistic human pathogen Pseudomonas aeruginosa causes rapidly progressive and tissue-destructive infections, such as hospital-acquired and ventilator-associated pneumonias. Innate immune responses are critical in controlling P. aeruginosa in the mammalian lung, as demonstrated by the increased susceptibility of MyD88(-/-) mice to this pathogen. Experiments conducted using bone marrow chimeric mice demonstrated that radio-resistant cells participated in initiating MyD88-dependent innate ...[more]
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