Ontology highlight
ABSTRACT:
SUBMITTER: Zanucco E
PROVIDER: S-EPMC3237599 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Zanucco Emanuele E Götz Rudolf R Potapenko Tamara T Carraretto Irene I Ceteci Semra S Ceteci Fatih F Seeger Werner W Savai Rajkumar R Rapp Ulf R UR
PloS one 20111214 12
Growth factor induced signaling cascades are key regulatory elements in tissue development, maintenance and regeneration. Perturbations of these cascades have severe consequences, leading to developmental disorders and neoplastic diseases. As a major function in signal transduction, activating mutations in RAF family kinases are the cause of human tumorigenesis, where B-RAF V600E has been identified as the prevalent mutant. In order to address the oncogenic function of B-RAF V600E, we have gener ...[more]