Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe-Takano H
PROVIDER: S-EPMC4050578 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Watanabe-Takano Haruko H Takano Kazunori K Sakamoto Akemi A Matsumoto Kenji K Tokuhisa Takeshi T Endo Takeshi T Hatano Masahiko M
Proceedings of the National Academy of Sciences of the United States of America 20140519 22
Alveolar formation is coupled to the spatiotemporally regulated differentiation of alveolar myofibroblasts (AMYFs), which contribute to the morphological changes of interalveolar walls. Although the Ras-ERK signaling pathway is one of the key regulators for alveolar formation in developing lungs, the intrinsic molecular and cellular mechanisms underlying its role remain largely unknown. By analyzing the Ras-ERK signaling pathway during postnatal development of lungs, we have identified a critica ...[more]