Ontology highlight
ABSTRACT:
SUBMITTER: Larimore J
PROVIDER: S-EPMC3237628 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Larimore Jennifer J Tornieri Karine K Ryder Pearl V PV Gokhale Avanti A Zlatic Stephanie A SA Craige Branch B Lee Joshua D JD Talbot Konrad K Pare Jean-Francois JF Smith Yoland Y Faundez Victor V
Molecular biology of the cell 20111012 24
Dysbindin assembles into the biogenesis of lysosome-related organelles complex 1 (BLOC-1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common endosome-trafficking route. Deficiencies in AP-3 and BLOC-1 affect synaptic vesicle composition. However, whether AP-3-BLOC-1-dependent sorting events that control synapse membrane protein content take place in cell bodies upstream of nerve terminals remains unknown. We tested this hypothesis by analyzing the targeting of phospha ...[more]