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Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

ABSTRACT: Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 ?M against H1325, H2122, and HCC366, respectively.

SUBMITTER: Hu Y

PROVIDER: S-EPMC3237914 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

Hu Youcai Y MacMillan John B JB

Organic letters 20111122 24

Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively. ...[more]

PMID: 22106936

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