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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity.

ABSTRACT: Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 ?M, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic.

SUBMITTER: Huang LH

PROVIDER: S-EPMC6155177 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity.

Huang Li-Hong LH Chen Yan-Xiu YX Yu Jian-Chen JC Yuan Jie J Li Hou-Jin HJ Ma Wen-Zhe WZ Watanapokasin Ramida R Hu Kun-Chao KC Niaz Shah Iram SI Yang De-Po DP Lan Wen-Jian WJ

Molecules (Basel, Switzerland) 20170311 3

Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass s ...[more]

PMID: 28287456

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