A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque.
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ABSTRACT:
SUBMITTER: Phipps JE
PROVIDER: S-EPMC3239410 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque.
Phipps Jennifer E JE Hatami Nisa N Galis Zorina S ZS Baker J Dennis JD Fishbein Michael C MC Marcu Laura L
Journal of biophotonics 20110719 9
Matrix metalloproteinase (MMP)-2 and -9 play important roles in the progression of atherosclerosis. This study aims to determine whether MMP-2 and -9 content in the fibrotic caps of atherosclerotic plaque is correlated with plaque autofluorescence. A time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) system was used to measure the autofluorescence and assess the biochemical composition of human plaques obtained from carotid endarterectomy. Results presented here demonstrate for the ...[more]
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