Ontology highlight
ABSTRACT:
SUBMITTER: Marcet-Palacios M
PROVIDER: S-EPMC3240606 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Marcet-Palacios Marcelo M Duggan Brenda Lee BL Shostak Irene I Barry Michele M Geskes Tracy T Wilkins John A JA Yanagiya Akiko A Sonenberg Nahum N Bleackley R Chris RC
PLoS pathogens 20111215 12
Cytotoxic T lymphocytes (CTLs) are the major killer of virus-infected cells. Granzyme B (GrB) from CTLs induces apoptosis in target cells by cleavage and activation of substrates like caspase-3 and Bid. However, while undergoing apoptosis, cells are still capable of producing infectious viruses unless a mechanism exists to specifically inhibit viral production. Using proteomic approaches, we identified a novel GrB target that plays a major role in protein synthesis: eukaryotic initiation factor ...[more]