Ontology highlight
ABSTRACT:
SUBMITTER: Zahreddine HA
PROVIDER: S-EPMC5705209 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zahreddine Hiba Ahmad HA Culjkovic-Kraljacic Biljana B Emond Audrey A Pettersson Filippa F Midura Ronald R Lauer Mark M Del Rincon Sonia S Cali Valbona V Assouline Sarit S Miller Wilson H WH Hascall Vincent V Borden Katherine Lb KL
eLife 20171107
The microenvironment provides a functional substratum supporting tumour growth. Hyaluronan (HA) is a major component of this structure. While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis in cancer are poorly understood. We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, drives HA biosynthesis. eIF4E stimulates production of enzymes that synthesize the building blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as ...[more]