Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi T
PROVIDER: S-EPMC3240965 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Scientific reports 20111205
Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-γ-inducible factor, spontaneously develop uterine LMS. The IFN-γ pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tiss ...[more]