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Heart failure-potential new targets for therapy.

ABSTRACT: INTRODUCTION/BACKGROUND:Heart failure is a major cause of cardiovascular morbidity and mortality. This review covers current heart failure treatment guidelines, emerging therapies that are undergoing clinical trial, and potential new therapeutic targets arising from basic science advances. SOURCES OF DATA:A non-systematic search of MEDLINE was carried out. International guidelines and relevant reviews were searched for additional articles. AREAS OF AGREEMENT:Angiotensin-converting enzyme inhibitors and beta-blockers are first line treatments for chronic heart failure with reduced left ventricular function. AREAS OF CONTROVERSY:Treatment strategies to improve mortality in heart failure with preserved left ventricular function are unclear. GROWING POINTS:Many novel therapies are being tested for clinical efficacy in heart failure, including those that target natriuretic peptides and myosin activators. A large number of completely novel targets are also emerging from laboratory-based research. Better understanding of pathophysiological mechanisms driving heart failure in different settings (e.g. hypertension, post-myocardial infarction, metabolic dysfunction) may allow for targeted therapies. AREAS TIMELY FOR DEVELOPING RESEARCH:Therapeutic targets directed towards modifying the extracellular environment, angiogenesis, cell viability, contractile function and microRNA-based therapies.

SUBMITTER: Nabeebaccus A

PROVIDER: S-EPMC5862241 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Heart failure-potential new targets for therapy.

Nabeebaccus Adam A Zheng Sean S Shah Ajay M AM

British medical bulletin 20160630 1

<h4>Introduction/background</h4>Heart failure is a major cause of cardiovascular morbidity and mortality. This review covers current heart failure treatment guidelines, emerging therapies that are undergoing clinical trial, and potential new therapeutic targets arising from basic science advances.<h4>Sources of data</h4>A non-systematic search of MEDLINE was carried out. International guidelines and relevant reviews were searched for additional articles.<h4>Areas of agreement</h4>Angiotensin-con ...[more]

PMID: 27365454

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Project description:Novel coronavirus pneumonia (COVID-19) is a new type of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has spread rapidly and become a global pandemic. Heart failure (HF) is the ultimate period of the development of various cardiovascular diseases. There are several research have found that SARS-CoV-2 infection may induce cardiac complications including enhanced cardiac stress biomarkers and heart failure. Our research aims at identifying underlying biological processes and key targets in COVID-19-associated heart failure via bioinformatics analysis. A total of three heart failure datasets and three COVID-19 datasets were obtained using the Gene Expression Omnibus (GEO) database. Batch effects cross each sample were eliminated with surrogate variable analysis algorithm. Then, we identified key modules of COVID-19 datasets and heart failure datasets through weighted gene co-expression network analysis. HF-associated as well as COVID-19-associated key modules were intersected for determining the shared genes of COVID-19-associated heart failure. The pivotal genes associated with COVID-19-related heart failure were determined by intersecting the shared genes with the HF-associated hub genes selected through WGCNA. Furthermore, we conducted GO as well as KEGG enrichment analysis on shared genes of COVID-19-associated heart failure. Two COVID-19-associated key modules as well as three HF-associated key modules were determined. In addition, eleven shared genes for COVID-19-associated heart failure were determined. In conclusion, our work screened two critical genes, namely PYGM and BLM, which may be possible intervention targets for COVID-19-associated heart failure. According to functional enrichment results, the shared genes of COVID-19-associated heart failure showed high enrichment in starch and sucrose metabolism, homologous recombination, Fanconi anemia pathway, and insulin resistance indicate the probably biological processes linked to COVID-19-associated heart failure. These results provided further insights in possible interventional and therapeutic targets of COVID-19-associated heart failure.

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Heart failure-potential new targets for therapy.

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Heart failure-potential new targets for therapy.

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