Ontology highlight
ABSTRACT:
SUBMITTER: Daikoku T
PROVIDER: S-EPMC3241866 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Developmental cell 20111117 6
An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when this molecular cross-talk is established. Here we show that the muscle segment homeobox gene (Msh) family members Msx1 and Msx2, which are two highly conserved genes critical for epithelial-mesenchymal interactions during development, also play crucial roles in embryo implantation. Loss of Msx1/Msx2 expr ...[more]