Ontology highlight
ABSTRACT:
SUBMITTER: Gerdemann U
PROVIDER: S-EPMC3242656 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Gerdemann Ulrike U Katari Usha U Christin Anne S AS Cruz Conrad R CR Tripic Tamara T Rousseau Alexandra A Gottschalk Stephen M SM Savoldo Barbara B Vera Juan F JF Heslop Helen E HE Brenner Malcolm K MK Bollard Catherine M CM Rooney Cliona M CM Leen Ann M AM
Molecular therapy : the journal of the American Society of Gene Therapy 20110913 12
Although immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) can treat EBV-associated Hodgkin and non-Hodgkin lymphoma (HL/NHL), more than 50% of such tumors are EBV negative. We now describe an approach that allows us to consistently generate, in a single line, CTLs that recognize a wide spectrum of nonviral tumor-associated antigens (TAAs) expressed by human HL/NHL, including Survivin, MAGE-A4, Synovial sarcoma X (SSX2), preferentially expressed antigen in melan ...[more]