Ontology highlight
ABSTRACT:
SUBMITTER: Basha G
PROVIDER: S-EPMC3242662 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Basha Genc G Novobrantseva Tatiana I TI Rosin Nicole N Tam Yuen Yi C YY Hafez Ismail M IM Wong Matthew K MK Sugo Tsukasa T Ruda Vera M VM Qin June J Klebanov Boris B Ciufolini Marco M Akinc Akin A Tam Ying K YK Hope Michael J MJ Cullis Pieter R PR
Molecular therapy : the journal of the American Society of Gene Therapy 20111004 12
Lipid nanoparticles (LNPs) are currently the most effective in vivo delivery systems for silencing target genes in hepatocytes employing small interfering RNA. Antigen-presenting cells (APCs) are also potential targets for LNP siRNA. We examined the uptake, intracellular trafficking, and gene silencing potency in primary bone marrow macrophages (bmMΦ) and dendritic cells of siRNA formulated in LNPs containing four different ionizable cationic lipids namely DLinDAP, DLinDMA, DLinK-DMA, and DLinKC ...[more]