Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4307782 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Wang Xinmei X Yu Bo B Ren Wei W Mo Xiaokui X Zhou Chenguang C He Hongyan H Jia Huliang H Wang Lu L Jacob Samson T ST Lee Robert J RJ Ghoshal Kalpana K Lee L James LJ
Journal of controlled release : official journal of the Controlled Release Society 20131008 3
Many cationic lipids have been developed for lipid-based nanoparticles (LNPs) for delivery of siRNA and microRNA (miRNA). However, less attention has been paid to "helper lipids". Here, we investigated several "helper lipids" and examined their effects on the physicochemical properties such as particle size and zeta potential, as well as cellular uptake and transfection efficiency. We found that inclusion of oleic acid (OA), an unsaturated fatty acid, into the LNP formulation significantly enhan ...[more]