Ontology highlight
ABSTRACT:
SUBMITTER: Huang G
PROVIDER: S-EPMC3242717 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Huang Gang G Zhao Xinghui X Wang Lan L Elf Shannon S Xu Hao H Zhao Xinyang X Sashida Goro G Zhang Yue Y Liu Yan Y Lee Jennifer J Menendez Silvia S Yang Youyang Y Yan Xiaomei X Zhang Pu P Tenen Daniel G DG Osato Motomi M Hsieh James J-D JJ Nimer Stephen D SD
Blood 20111019 25
The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBFβ transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in human acute leukemia. We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2 critical regulatory regions of the AML1 target gene PU.1. Similar to CBFβ, we show th ...[more]