Ontology highlight
ABSTRACT:
SUBMITTER: Di Talia S
PROVIDER: S-EPMC3643212 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Di Talia Stefano S Wieschaus Eric F EF
Developmental cell 20120405 4
Cells commit to mitosis by abruptly activating the mitotic cyclin-Cdk complexes. During Drosophila gastrulation, mitosis is associated with the transcriptional activation of cdc25(string), a phosphatase that activates Cdk1. Here, we demonstrate that the switch-like entry into mitosis observed in the Drosophila embryo during the 14(th) mitotic cycle is timed by the dynamics of Cdc25(string) accumulation. The switch operates as a short-term integrator, a property that can improve the reliable cont ...[more]