Ontology highlight
ABSTRACT:
SUBMITTER: Donnelly CJ
PROVIDER: S-EPMC3243598 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Donnelly Christopher J CJ Willis Dianna E DE Xu Mei M Tep Chhavy C Jiang Chunsu C Yoo Soonmoon S Schanen N Carolyn NC Kirn-Safran Catherine B CB van Minnen Jan J English Arthur A Yoon Sung Ok SO Bassell Gary J GJ Twiss Jeffery L JL
The EMBO journal 20110930 22
Subcellular localization of mRNAs is regulated by RNA-protein interactions. Here, we show that introduction of a reporter mRNA with the 3'UTR of β-actin mRNA competes with endogenous mRNAs for binding to ZBP1 in adult sensory neurons. ZBP1 is needed for axonal localization of β-actin mRNA, and introducing GFP with the 3'UTR of β-actin mRNA depletes axons of endogenous β-actin and GAP-43 mRNAs and attenuates both in vitro and in vivo regrowth of severed axons. Consistent with limited levels of ZB ...[more]