Ontology highlight
ABSTRACT:
SUBMITTER: Sahoo PK
PROVIDER: S-EPMC6105716 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180822 1
Critical functions of intra-axonally synthesized proteins are thought to depend on regulated recruitment of mRNA from storage depots in axons. Here we show that axotomy of mammalian neurons induces translation of stored axonal mRNAs via regulation of the stress granule protein G3BP1, to support regeneration of peripheral nerves. G3BP1 aggregates within peripheral nerve axons in stress granule-like structures that decrease during regeneration, with a commensurate increase in phosphorylated G3BP1. ...[more]