Ontology highlight
ABSTRACT:
SUBMITTER: Hock AK
PROVIDER: S-EPMC3243628 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Hock Andreas K AK Vigneron Arnaud M AM Carter Stephanie S Ludwig Robert L RL Vousden Karen H KH
The EMBO journal 20111115 24
The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by the ubiquitin ligase MDM2. In this study, we have identified USP42 as a DUB that interacts with and deubiquitinates p53. USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase o ...[more]